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Metformin belongs to the class of drugs known as biguanides. Glucophage should be taken with meals. You are taking this medicine. Metformin decreases the amount of sugar in the blood. Glucophage is from the biguanide class of oral anti-hyperglycemic agents. Metformin increases the sensitivity of muscle cells to insulin. Glucophage is from the biguanide class of oral anti-hyperglycemic agents.