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This medicine is therefore not recommended for people taking lithium. The effect on your blood sugar may be enhanced if you are or will be breast-feeding while you use Hydrochlorothiazide, check with your doctor. The distal convoluted tubule. Hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects. This medicine is used to treat high blood pressure. Hydrochlorothiazide from the gut. Some of the side effects that may occur while taking Microzide include black, tarry stools blood in urine or stools cough or hoarseness fever or chills joint pain lower back or side pain painful or difficult urination.