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Before taking Prednisolone, you should tell your doctor about all of your medical conditions and about all other medicines you are using. Prednisone and Prednisolone are considered to be intermediate acting steroids, meaning that a dose lasts about a day or a day and a half. Prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Prednisolone is a corticosteroid medicine. Prednisone is used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. If you have a fungal infection anywhere in your body. It should be ensured that if antibiotics are required, that they are given in effective doses. Prednisone is inactive in the body.