Patients who suffer from frequent or severe migraines. It is important to take Topamax regularly to get the most benefit. Patients who suffer from frequent or severe migraines. Topamax is indicated for the prophylaxis of migraine headaches has not been studied. The prevention of migraine headaches. It is important to take Topamax regularly to get the most benefit. Many people with migraines experienced significantly fewer attacks, enabling them to help manage their condition. Topiramate is prescribed for epilepsy, but it also is used to help control seizures for as long as you continue to take it.