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Celexa causes less drug interactions, you should always let your doctor know what other medications you are taking. Celexa is the newest antidepressant to be approved by theFDA. Take for granted. Celexa appears to be safe to use on a long-term basis and may cause less withdrawal when use is stopped. Celexa insomnia may be a side effect from this drug prolonging serotonin's action within the brain.