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The infection, which is responsible for the majority of gastric ulcers. What should my health care professional know before I take Esomeprazole? In the stomach, Nexium reduces the amount of acid backing up into the esophagus and causing reflux symptoms. If taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Nexium capsules should be applied one hour before meals and at the same time every day. Nexium is the newer formulation of the original Omeprazole product - both prescription drugs used to treat and prevent stomach and intestinal ulcers, damage to the esophagus from stomach acid, and other conditions involving excessive stomach acid production.