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The skin, urinary tract, respiratory tract, bones, and joints. If you're feeling better in a few days. Keflex is effective antibiotic therapy for skin and skin structure infections and is the most prescribed oral cephalosporin medicine. Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Although side effects from Cephalexin are not common, they can occur. Although some side effects can be serious. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Patients taking other cephalosporin antibiotics can not take additional cephalosporin antibiotics as this is likely to result in an overdose.