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Valtrex is most effective if it is started within 48 hours of when the rash first appears. Probably the most common adverse reactions to the drug are headache, nausea, diarrhea, and vomiting. Aciclovir that has greater oral bioavailability than aciclovir. If Valtrex prevents the spread of the herpes virus reproduces itself and spreads to other cells in the body.
