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Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. Prednisone typically does not produce immediate effects and must be used for several weeks or even months at a time to get a chronic process under control. Prednisone is the most commonly-prescribed oral corticosteroid. Before taking Prednisolone, you should tell your doctor about all of your medical conditions and about all other medicines you are using. Prednisolone is commonly used for several days before the needed effect is achieved.