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The prevention and long-term treatment of asthma. Before taking Montelukast, tell your doctor or pharmacist of all prescription and nonprescription products you may use which stimulate liver metabolism. Montelukast works by blocking substances and their relative functions in the body called leukotrienes. Keep a diary of the time, frequency, and severity of your asthma attacks for the first three months after starting Singulair. Singulair can be taken with or without food, and a once daily, usually in the evening. This drug improves asthma and hay fever symptoms by blocking substances in the body called leukotrienes. Singulair is a prescription tablet, approved to help control asthma in adults and to relieve symptoms of indoor as well as outdoor allergies. Montelukast works by blocking substances in the body that trigger allergic and asthmatic reactions.