Fluconazole is a triazole antifungal agent that can be administered orally or parenterally. Diflucan comes as a tablet and liquid to take by mouth. Fluconazole disturbs the production of ergosterol that is essential component of the fungi cell, resulting in changing permeability. Diflucan comes as a tablet and liquid to take by mouth. Before taking Diflucan, tell your doctor if you are pregnant or could become pregnant during treatment. Fluconazole appears to be a safe and effective treatment for cutaneous leishmaniasis.