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Take by mouth. Metformin works by helping to restore your body's proper response to the insulin you naturally produce, and by decreasing the amount of sugar produced by cells in the liver. Metformin reduces the amount of sugar that your liver makes and that your stomach absorbs. Overall, Metformin reduces blood sugar levels can rise too high. In type 2 diabetes. Most obese patients are insulin resistant, and increasingly the type-2 diabetes medication Metformin is being prescribed to increase glucose sensitivity and promote weight loss process. Metformin reduces the amount of sugar produced by cells in the liver.