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The tablets or Premarin vaginal cream, you should be aware that this product can weaken latex condoms. Long-term treatment with conjugated estrogens may increase your risk of stroke or blood clots. What is the most important information I should know about conjugated estrogens? You should be aware that this product can weaken latex condoms. Women who are no longer producing proper amounts. Long-term treatment with conjugated estrogens may increase your risk of developing these conditions. Because Premarin can increase the risk of heart attack, and certain estrogen-dependent cancers, contact your doctor right away if you notice sudden shortness of breath or abnormal bleeding from the vagina. In women who are no longer producing proper amounts. Conjugated estrogens treatment may increase your risk of breast cancer.