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Paxil should be taken once a day, either in the morning or evening, with or without food. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. This population. It may take one month or more for you to start feeling better. Paroxetine can cause side effects that may impair your thinking or reactions. Do not take Paxil without first talking to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight. Depression, obsessive-compulsive disorder, anxiety, or an eating disorder, the drugs, known as selective serotonin reuptake inhibitors, may bring relief. With depression, the most severe cognitive and behavioral malfunctions are expressed in what is called a major depressive disorder, as stated by others.