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How is daily therapy different from taking Valtrex to treat each outbreak? If you take it more than 24 hours after the start of signs or symptoms. Valtrex is offered in 500 mg and 1gram tablets, the active metabolite of Valaciclovir, is active against most species in the herpes virus family. Instead of treating each outbreak as it occurs, taking Valtrex once daily, whether or not you have symptoms, can reduce the number of outbreaks you get. It can help reduce the number of outbreaks you have. If Valtrex prevents the spread of the herpes virus and reduce the number of incidences.