The first-line drugs, particularly in treatment of infections. In allergy to Fluconazole or other anti fungal azole preparations. Do not stop taking Diflucan without talking to your doctor. Fluconazole is used to treat vaginal yeast infections. Diflucan comes as a tablet and liquid to take by mouth. Do not stop taking Diflucan right away. Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system. Before taking Fluconazole, tell your doctor if you are pregnant or could become pregnant during treatment. Diflucan should not be construed to indicate that use of Diflucan is safe, appropriate, or effective for you.