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Serious side effects of Plavix, also known as Clopidogrel bisulfate, include bleeding and, rarely, low white blood cell counts and low platelet counts with spontaneous bleeding and clotting. Plavix, now the world's second best-selling drug, received FDA approval to thin the blood and prevent clots that can occur with certain heart or blood vessel conditions. Plavix, now the world's second best-selling drug, received FDA approval to thin the blood and prevent clots that can occur with certain heart or blood vessel conditions. Clopidogrel can decrease the chance of a heart attack or stroke, and in people with certain disorders of the heart or blood vessels. Meanwhile, online pharmacies are offering discounts on Plavix, hoping the cheaper generic drug will maintain its market share. Meanwhile, online pharmacies are offering discounts on Plavix, hoping the cheaper generic drug will maintain its market share. Meanwhile, online pharmacies are offering discounts on Plavix, hoping the cheaper generic drug will maintain its market share.