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Do not take Paxil without first talking to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight. You are now taking an FDA-approved medication proven safe and effective for long-term use and is well tolerated. Research has shown that depression and anxiety disorders could be linked to a chemical imbalance in the brain. Depression and anxiety disorders usually require long-term treatment because of their chronic nature and the risk of relapse. Research has shown that depression and anxiety disorders usually require long-term treatment because of their chronic nature and the risk of relapse.