Your body adjusts to the medication. Acyclovir is usually taken two to five times a day for five days, starting as soon as you feel the tingle of a cold sore. Wash your hands before and after applying Acyclovir topical. Be started as soon as possible after your symptoms begin. Acyclovir is an antiviral drug that is available under the trade name Zovirax, in oral, intravenous, and topical forms. Sometimes acyclovir is given to help prevent the infection from coming back. If your cold sore has not healed after five days of treatment, it may be continued for up to ten months.
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