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Take Accutane two times a day with a meal, unless your doctor tells you otherwise. Because he or she has judged that the benefit to you is greater than the risk of side effects. Isotretinoin is used to treat severe acne that is resistant to more conservative treatments such as creams, drying agents, and topical or oral antibiotics. Accutane comes as a capsule to take by mouth with or without food. Treatment usually leads to clearing of acne. After other treatments have been tried and found to be ineffective. Accutane need not be paired with other medications. Take more or less of it or take it more often than prescribed by your doctor.