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Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. You should not stop taking this medicine suddenly, particularly if you have ischemic heart disease. You should not stop taking this medicine suddenly, particularly if you have ischemic heart disease. If you have ischemic heart disease. Propranolol reduces the workload of the heart at any level of effort by blocking catecholamine induced increases in the heart rate, tremor and nausea. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area.