Prednisone is the most commonly-prescribed oral corticosteroid. Prednisolone prevents the release of substances in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver. Prednisone to Prednisolone is impaired. Before taking Prednisolone, you should tell your doctor about all of your medical conditions and about all other medicines you are using. Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body.