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In the fungal infection Cryptococcus. To a group of medications called antimycotic or antifungal. Diflucan comes as a tablet and liquid to take by mouth. Fluconazole is commonly used for prophylaxis in transplant patients. In common with all azole antifungal agents, Fluconazole may cause hepatotoxicity. Fluconazole works best when the amount of medicine in your body is kept at a constant level.