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Your medical conditions and about all other medicines you are using. Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body, but they most often are used for their potent anti-inflammatory effects, particularly in those conditions in which the immune system plays an important role. If antibiotics are required, that they are given in effective doses. In the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly.